Hi CF,
I don't think so. SCCP has been supported with the VG224 and CCM since the 3.3.x train. Perhaps there are some new features that would work only with CCM 4.2 but that should be it;
Cisco VG 224 Analog Phone Gateway
Cisco Unified CallManager 3.3.3 SR2 or higher version
http://www.cisco.com/en/US/products/hw/gatecont/ps2250/products_data_sheet09186a00801d87f6.html
Hope this helps!
Rob