In general it will behave exactly the same way as when you configure it in a LAN, now there are some issues to consider:

With VPLS in its "l2 vfi" form, you can setup a point-to-point, point-to-multipoint and full-mesh logical architecture. You should consider this in your EIGRP configuration because you may experience some "split horizon" on point-to-multipoint setup.

Also, depending on how many CEs you are going to be including in your deployment, it is always recommend to tune-up the routing protocol. For example, you may need to consider the hello timers, updates times, "ip bandwidth-percent eigrp percent" and others.

-W