Hi Ali
access-list 101 deny tcp any any eq 445
access-list 101 permit ip any any
You then apply this to your L3 interfaces whether they be routed ports or Vlan interfaces wherever you have client PC's or servers.
ip access-group 101 in
The problem is though that port 445 is used by Windows for a lot of it's functionality and if you block this port a lot of the pc's functionality will not work eg. things such as file sharing for example.
Jon