We have an app server that is capable of supporting Ethernet frames up to 6K or so. Currently, it has redundant connections to a pair of Cat 4506 (Sup IV, IOS 12.2(25)EWA5) on 10/100/1000 48-port line cards. Both switches have a pair of Gig fiber trunks uplinked to redundant 6509 core switches (Sup 2,IOS 12.2(18)SXF3.) I have reviewed Cisco's documentation on enabling jumbo frame support on these switches, but on how many interfaces would I need it configured? The two interfaces on the 4500 switches are a given, but does it also need to be set on all the aforementioned trunked interfaces? Or does this have to be applied to nearly all datacenter switches, similar to uplinkfast/backbonefast commands?