Off the top of my head, using CBWFQ, you could define a class for each host and police or shape its traffic rate with a dedicated class. Two problems with this approach, not sure CBWFQ would support 300 classes (256 max?), and would be a problem to maintain.
e.g. (note syntax will be off)
ip access-list extended user1
permit ip host x.x.x.x any
ip access-list extended user2
permit ip host x.x.x.x any
class-map user1
match access-list user1
class-map user2
match access-list user1
policy-map traffic-control
class user1
police 8000
class user2
police 10000
serial x
service policy traffic-control out
Perhaps you might consider trying to control or prioritize the different types of traffic without regard to all your specific hosts. For instance, you could limit or deprioritze p-2-p traffic such that it would have little impact to more important traffic.
e.g. (note syntax will be off)
class-map low-priority match-any
match protocol BitTorrent
match protocol Gnutella
match protocol Kazaa2
match protocol eDonkey
match protocol Fasttrack
match protocol Napster
policy-map traffic-control
class low-priority
bandwidth percent 1
serial x
service policy traffic-control out
Also note, you can be very effective with outbound traffic control, much less so inbound unless you can configure the router on the other side of your Internet link.
