I got PIX515E that has been configured using PDM. I am more familiar on CLI commands that why everytime I made some changes I am doing it on CLI.Is there any conflict on the configuration if I continue using CLI or should I use PDM?
This is just my experience and it is based on pix v6.x software but i have always found it a very bad idea to use both to configure the same firewall. Things that can be configured on the command line are sometimes not recognised by PDM and PDM itself often adds unnecessary configuration.
My advice would to be to stick with one of them to configure the same device.