Hello Yann, it will not modify any configuration directly. But please remember the NAT order of operation:
http://www.cisco.com/en/US/docs/security/asa/asa72/configuration/guide/cfgnat.html#wp1042696
So lets say you have a rule now to translate 192.168.1.0/24 when going to outside (Internet). Now you add a rule that matches the same flow with a
nat (inside) 0 access-list nonat
This will have preference over the previous commands as NAT Exemption (nat 0 ACL) has highest priority. So just be careful about this.
Regards
Farrukh