Using Cisco VPN client v4.8.00.0440 (potentially newer versions too) I am hearing of users having a problem where the Host entry in their profile is "disapearing" but the rest of the profile details remain in place. This seems to be a very random problem, occuring maybe 1 in 10 conenction attempts. When the host entry is missing, the user can modify and save the profile and it will remain intact for an indefinite period. Then one time they will open the VPN client and it won't connect because of the missing host again. We haven't been able to determine any pattern or simlar conditions when this occurs for various users.
I have this problem too.