sure u can
this is example to u to block yahoo.com
regex web1 "\.yahoo\.com"
make acl to match the direction from where to where the traffic for this url to be block
lets say from inside to outside toward the internet
access-list url-acl extended permit tcp (ur inside network with mask) any eq www
class-map type regex match-any url-lists
match regex web1
(and u can add more regex matching here)
then
class-map type inspect http match-all url-block
match request header host regex class url-lists
class-map httptraffic
match access-list url-acl
policy-map type inspect http http-policy
class url-block
reset log
policy-map url-block-policy
class httptraffic
inspect http http-policy
then apply it to the source of your trafffic as we assumed the inside interface
sevice-policy url-block-policy interface inside
becarefull with matching statements any mistake may lead to not blocking
and becarefull also with the REGEX
good luck
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