Is it the mtu or the mss ?
Please try this on both pix ( if they are running 7.x or 8.x code ) :
access-list http-list2 permit ip any any
class-map http-map1
match access-list http-list2
exit
tcp-map mss-map
exceed-mss allow
exit
policy-map global_policy
class http-map1
set connection advanced-options mss-map
exit
exit
Please rate if helps.
Regards,
Sushil