ACNS can cache multiple protocols by default, however if you want to cache Windows Media and/or Real, there are licenses that you will need.

You can deploy a stand alone (or multiple) ACNS Cache and use the CLI to configure them easily. Here is a link for configuring ACNS stand alone boxes.

http://www.cisco.com/en/US/docs/app_ntwk_services/waas/acns/v55/configuration/local/guide/55ldg.html

If you have other ACNS CEs in the network, or want the functionality of a centralized management and reporting box, then use a CDM.

http://www.cisco.com/en/US/docs/app_ntwk_services/waas/acns/v55/configuration/central/guide/55cdg.html

Basically I would use WCCP or a L4-7 switch (proxy.pac is also used) to intercept and direct the traffic to one or more ACNS CEs, it's very handy to be able to load balance multiple boxes for higher levels of traffic. On ACNS, you can use rules to enforce object caching, deny caching, block sites, etc. That is where the CDM comes in handy, so you can push the same rules down to all the boxes at once. There are also all kinds of HTTP protocol tweaks.

Hope that helps,

Dan