Not sure if anyone else has ever run into something like this. I've been testing the below scenarios and am getting the same results.
-If users connect to the ASA via the web page, they can login and successfully connect to the vpn.
-If they launch the client locally, the certificate pops up but then fails the connection saying unable to process a response.
WebVPN is currently using port 8080. Thinking this might be causing a problem, I changed it back to 443 with the same results.