Hi there!
What do you mean when you are saying QoS? Queueing, policing, shaping...?
Depending on the bandwith, services and if the connection is a L2 or L3, I would recommend to configure there at least some queueing mechanism to give prioritiy to some classes of traffic (e.g. LLQ for VoIP). If you have plenty of bandwidth you don't have to worry about shaping or policing, if you don't need to explicit limit a network class to a certain amount fo bandwidth.
Everything which I said above, is depending where you are using this 2 C6500. WAN or LAN. I would say LAN, but you never now.
Let us know more details to be able to help.