Jumbo Frames are a good thing. Make sure the MTUs agree on both ends (though it is a one-way negotiation, some drivers use the receives side MTU to set the output MTU). Maybe bump your NIC's input buffers as well.
The usual stuff also applies: update your NIC drivers to current, make sure the NIC is in a slot that is not sharing interrupts and DMA with another high-demand device, check the cable for proper pinout and excellent condition (no kinks, twists, stretches, nicks in the jacket, strain relief, minumum bend radius, etc).
Good Luck
Scott