your ACS version should definitely be compatible with 2008 server.
from ACS 5.2 onwards it is compatible with 2008 server.
the below line is just to show that your version is ok and need to check with some other issues.
This occurs because of incompatibility issues. AD 2008 R2 integration is supported from ACS 5.2 version only. Upgrade your ACS to 5.2 or later. Refer to Cisco bug ID CSCtg12399 (registered customers only) for more information.
Yes, it does support Windows 2008 R2. The support was introduce from ACS 5.2
The root cause of this error message can only be seen in the adclient logs.
From my experience, I can tell you that this will be fixed with patch 4 or above. Else, get the adclient logs and we can tell you what could be a problem. Most of the ACS-AD communication were addressed in ACS 5.3 patch 4 and above.
I also want to know in case you changed the ACS host name while ACS is join to AD?
Can you also post the output of "show timezone" and "show clock".
ACS 5.3 issue of integration with the AD is known issue and was resolved in the patch 4 or above, or if you still having the same issue please send us the logs, so that we can go through it and resolve your issue timely.
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