Yes you can using 'sorry' servers.
The concept of Sorry servers is to provide backup when the normal or regular servers are down. While any of the normal servers are operational the Sorry servers are not part of the load balancing mechanism. When all normal servers fail the primarySorryServer will handle all flows from the CSS until any of the regular servers come up. At this time the secondarySorryServer is not getting any flows. If all normal servers go down and the primarySorryServer also goes down the secondarySorryServer will receive any HTTP requests and flows.
The following is an example of a rule that contains sorry services:
Content rule1
vip address 192.168.1.100
protocol tcp
port 80
url ?/*?
add service server1
add service server2
primarySorryServer server3
secondarySorryServer server4
active
Hope this would help you.
thanks