stickyness means new connections get sent to the same backend-server based on some critiria like source ip address or a cookie ...
Persistence means one TCP can connection can carry multiple http requests/responses.
So, you can decide to keep the persistence which means keep the connection to the same server for each request/response or you can break the persistence and break the connection into multiple ones on the backend for each request/response.
You usually want to break persistence to handle proxies that use a single connection for multiple clients.
You are corrcect. Persistance-rebalance will treat every HTTP request within the same TCP connection as an independent request allowing the ACE to forward a request to a different layer 7 rule. As Gilles mentioned it would be ideal to break the connection when clients are coming through a proxy. Also, if the client is coming from a network where TCP optimization is enabled.
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