It all depends on the virus, they all behave differently and you must tackle the disinfection process differently. First you need to isolate which PC has the virus, then determine what virus and variant you've got. There are many softwares that can assist you in this task. Once you have removed the infected PC from the network for maintenance, it is wise to determine the attack vector and purpose of the virus so you can take measures to prevent repeat infections and mitigate problems caused by the initial infection.
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