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vmware clusters and L2 Spanning

Server  virtualization and coud computing are the driving forces behind the  need to span a network's L2 domain. This is where TRILL comes into play.  You get horizontal scale-out in a flattened network, with multiple L2  forwarding paths powered by TRILL.

The  question I have is just how far across the data center does the L2  domain really need to span? Lets say this is a vmware environment. The  latest version of vSphere allows up to 32 hosts per cluster.  Furthermore, it is only within that 32-host cluster that a vmotion or  DRS or FT action can take place. Theoretically, you can configure the  vmware cluster to span the entire server farm, end-to-end. But in  reality, how are vmware clusters configured? I would think that the  hosts in a cluster are largely configured in adjacent cabinets, not  across the entire data center. So, do you REALLY need to span the L2  domain across the entire data center server farm?