That means port is unreachable and from your error message since it's UDP/53, the DNS resolution either does not work, or it already passes through the timeout for DNS reply. As a safety measure the firewall will drop the packet if it doesn't receive the DNS reply within certain period of time, this is to prevent against DNS attack.
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We have configured the outside and inside Interface with official ipv6 adresses, set a default route on outside Interface to our router, we also have definied a rule , which also gets hits, to permit tcp from inside Interface to any6.
In Syslog I also se...