Is it really during work or perhaps after lunch break? We had similar complaints but only with certain applications. People expierienced freezes on DB applications or Citrix (older Clients) usually after they'd been for a coffee or for lunch.
The standard TCP timeout in the FWSM is 60 minutes - and some applications seem not to make use of keepalives. Perhaps it would help to increase the timeout value.
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We have configured the outside and inside Interface with official ipv6 adresses, set a default route on outside Interface to our router, we also have definied a rule , which also gets hits, to permit tcp from inside Interface to any6.
In Syslog I also se...