Well, if it is 'incompatable' it will not install. If you're curious if any rules that you apply will hinder any operation, sure. My suggestion for the installation is to follow the install guide, and ensure the systems are in there with regard to O/S and system resources.
With regards to rule sets, leave them in test mode while you see what alerts are firing. The install doc does an OK job explaining how you should go about weeding those pertinent alerts from those that are system traffic.
Without knowing what the O/S is of each machine off the top, I'll assume Windows and with that, you'll be fine.
Table of ContentsIntroductionVersion HistoryPossible Future
UpdatesDocuments PurposeNAT Operation in ASA 8.3+ SectionsRule Types
Network Object NATTwice NAT / Manual NATRule Types used per SectionNAT
Types used with Twice NAT / Manual NAT and Network Obje...
Table of Contents Introduction:This document describes details on how
NAT-T works. Background: ESP encrypts all critical information,
encapsulating the entire inner TCP/UDP datagram within an ESP header.
ESP is an IP protocol in the same sense that TCP an...