The UC500 series product is a bundle of other products cramed into a single chassis. CME is one of these features as is CUE, VPN, firewall, and PSTN gateway functionality. I won't speak to pricing here; this is something that you should work out with your Cisco partner/reseller.
The main deciding factor should be scalability. What will your needs be in the next X years that you expect the equipment to last? Craming everything into one box tends to impose lower scalability limits.
Jonathan makes good points. Particularly about scalability. If you are looking at a single small office or a handful of small offices I think either product would be OK and basically equivalent (compare prices).
The other consideration is support. UC500 is not handled by regular TAC and SmartNet. They have their own small business support group.
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The short answer is that you don't.... That isn't entirely true while at
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Topology: IP Phone > Switches > Microsoft NPS setup to forward 802.1x
proxy to > ISE 2.1 patch 3 Authentication: EAP-TLS using Cisco MIC SANs
Phone Models 802.1X support? 802.1x flavor Addtl Comment EAP-MD5 EAP-TLS
Cisco 3905 Y Y N Cisco 6911 Y Y N Cisco ...