No unfortunately not :-). The 3750-E is a further development in the hardware architecture however it can be stacked with existing 3750 switches. From the 3750-E Q&A
"Q. What are the notable differences/features between the Cisco Catalyst 3750-E and the Cisco Catalyst 3750?
A. The differences are as follows:
â¢ Cisco Catalyst 3750-E provides a true line-rate (nonblocking) Gigabit Ethernet to the desktop solution with two line-rate 10 Gigabit Ethernet uplinks.
â¢ The Cisco Catalyst 3750-E is a stackable switch, and it is backward compatible and stacks with the existing Cisco Catalyst 3750 family switches.
â¢ The Cisco Catalyst 3750-E has a backplane switching ASIC, which also makes forwarding decisions, to help the switch perform wire-rate local switching.
â¢ The Cisco Catalyst 3750-E supports dynamic a pluggable module that converts a 10 Gigabit Ethernet slot into a slot that can fit 2 Gigabit Ethernet ports. This allows for easy migration for customers moving from Gigabit Ethernet uplinks to 10 Gigabit Ethernet uplinks.
â¢ The Cisco Catalyst 3750-E supports hot-swappable power supplies.
â¢ The Cisco Catalyst 3750-E supports jumbo frame routing and increases the frame size to 9216 bytes.
â¢ The Cisco Catalyst 3750-E supports uncompressed IPv6 address tables. This allows the software to program the full IPv6 address in the hardware. In addition, equal cost routing for IPv6 uses the uncompressed IPv6 address.
â¢ The Cisco Catalyst 3750-E supports destination stripping of unicast packets.
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