Hi Gavin
Yes, you can use HSRP for this, indeed this is exactly what HSRP was designed for.
Do you have a layer 2 trunk between your 2 6500 chassis ?
If so it is fairly straighforward eg.
6509_1
interface Vlan50
description xxxx
ip address 10.181.120.2 255.255.255.12
no ip redirects
standby 50 ip 10.181.120.1
standby 50 timers 1 5
standby 50 preempt
standby 50 authentication "xxx"
6509_2
interface Vlan50
description xxxx
ip address 10.181.120.3 255.255.255.128
standby 50 ip 10.181.120.1
standby 50 timers 1 5
standby 50 priority 50
standby 50 authentication "xxx"
Then set the default gateway on your host to point to 10.181.120.1
HTH
Jon