Advantage: Workstations behind edge ports need portfast enabled to make sure they connect to the network without typical spanning tree delays.
Advantage: Bpduguard ensures that if somebody tries to put a L2 device on the network. it is clipped before possible interruption of spanning tree.
Disadvantage: portfast - no disadvantages I know of for access level switch edge ports.
Disadvantage: bpduguard - If you ever need to just plug a switch into an acces switch port for whatever reason, you'll have to get to the CLI of the access switch and disable bpduguard on the subject port.
The golden rule is that if specific ports on a switch are never expected to have anything but end user devices connected, then active portfast and bpduguard on those ports. It's safe, helps keep the user experience positive, and keeps detrimental spanning-tree surprises from jumping up and biting you when you least expect it.
Hope this helps.
