When dual supervisor engines are in use in a Cisco Catalyst 4507R chassis, the ports 1/2 and 2/2 do not function. This behavior is by design, and there is no hardware problem.
In a Cisco Catalyst 4507R switch that uses Supervisor Engine IV modules, the design of the dual uplinks is to work when only one supervisor engine is present. The design works like this:
For more information, refer to the Supervisor Uplink Redundancy section of High Availability and Redundancy in Catalyst 4500 Series Switches.