You can use these cd's to upgrade the currently installed LMS 2.2 or you can install fresh. The license is what determines how the product will work afterwards. If you install clean then you will need to run the validateupgrade command to validate your license from an LMS 2.2 server or one of the LMS 2.2 cd's.
Keep in mind, that you can only install the applications based on you license. So, you could install CM as a standalone machine, but you will not be able to install it again anywhere if you only have a license for one server.