You can use the 'spanning-tree bpdufilter enable' command on the interface. This disables BPDUs on the interface. need IOS 12.1(12c)EW at least.
http://www.cisco.com/univercd/cc/td/doc/product/lan/cat4000/12_1_14/cmdref/s1.htm#81839
Caution Use care when entering the spanning-tree bpdufilter enable command. Enabling BPDU filtering on an interface is approximately equivalent to disabling the spanning tree for this interface. It is possible to create bridging loops if this command is not correctly used
Also, you could make the interface a L3 / routed interface to disable spanning tree but the device would have to be in its own subnet then.