int eth 0
ip address 10.0.0.1 255.255.255.0
ip nat inside
int ser 0
ip address 65.22.22.22 255.255.255.252
ip nat outside
ip nat inside source list 1 int serial0 overload
access-list 1 permit 10.0.0.0 0.0.0.255
You don't have to assign the outside address to an ethernet interface. The example above uses an internal network of 10.0.0.0/24 using NAT overload (PAT) on a single outside address.
See also:
Cisco - Configuring Network Address Translation: Getting Started - IP Addressing Services -
http://www.cisco.com/en/US/tech/tk648/tk361/technologies_tech_note09186a0080094e77.shtml#topic3