I am not sure if this is true, but I would think by nature of the pix that there can only be ONE outside since it has the lowest security rating. Everything else is considered inside to that interface. I would guess that if you had users on lets say DMZ3 that group could be routed to the second ISP. You would give that interface a Nat and a Global command and route there traffic. So I guess what I am saying is yes I think that is possible. If you happen to do this I would love to know if it worked.