Are you using 'alias' command on pix, if so, you need to disable proxyarp for that interface as part of the alias implemetation starts proxy arping for that IPs, therefore, you need to disable proxyarp in conjunction with alias command.
CSCdu74759 (Alias command for DNS fixup requires disabling proxy arp)
other related bugs
CSCdt01808
CSCdt01825
HTH
R/Yusuf