We do not have enough information to be sure about what the heck is going on but it sure does sound like you changed the IP address on the inside interface and that now devices on the inside (including your desktop) are attempting to communicate with the ASA using an address that is no longer the address of the ASA.
One thing about this situation that puzzles me is that if you were configuring the ASA for ASDM how does that lead you to configure an IP address on the inside interface? To enable ASDM you need to be sure that the correct version of ASDM code is loaded in flash, you need the configuration to point to that ASDM file, and you need to specify what source addresses can use ASDM.
We are pleased to announce availability of Beta software for 16.6.3. 16.6.3 will be the second rebuild on the 16.6 release train targeted towards Catalyst 9500/9400/9300/3850/3650 switching platforms. We are looking for early feedback from custome...