There are a lot of factors to take into consideration but as far as security goes, make sure you don't use WEP. There is no need to be using WEP anymore as WPA (TKIP) is available on Cisco products starting with the 350 and up if you use the IOS image. As WEP security is easily compromised, I would advise against.
Since you have 3 floors, you might need more than one AP so I would look into setting up CCKM/WDS. You will need a 1100 or 1200 series AP for that.
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