Hi,
CRTP is supported on/and should be enabled on a point ot point basic i.e. between CE1 and R, and betwenn each R-to-R links and finally between R-CE2. This would mean you'll go between series of compresson and decompression as you travell through the intermediate router links.
If R-R-R-R and layer 3 link then the statement above is through but if they are layer 2 wan link i.e. a frame-relay or ATM wan switch then you need only enable CRTP between CE1 and CE2 as wan switch is done with the Frame-relay frame header or ATM Cell header.
Hope it helps
Regards
Tola.