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Cisco Anyconnect Through Site-to-Site IPSec VPN

We are using a site-to-site VPN using a SPA on a 6500, that works fine.  However, when a user loads their client Anyconnect that terminates on an ASA through the siste-to-site VPN they can no longer reach devices behind the ASA.  The client Anyconnect will work at another site that is not going through the SPA.  We are uing a GRE tunnel running ospf over it, we think it might have something to do with the MTU.  We are setting the ip tcp adjust-mss 1350.

Has anybody experienced this problem before.

Thanks in advance.

Bob

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