Disclaimer
The Author of this posting offers the information contained within this posting without consideration and with the reader's understanding that there's no implied or expressed suitability or fitness for any purpose. Information provided is for informational purposes only and should not be construed as rendering professional advice of any kind. Usage of this posting's information is solely at reader's own risk.
Liability Disclaimer
In no event shall Author be liable for any damages whatsoever (including, without limitation, damages for loss of use, data or profit) arising out of the use or inability to use the posting's information even if Author has been advised of the possibility of such damage.
Posting
Can't say its best, or speak on what most might do, but I prefer, if possible, to treat VPN site-to-site, from a routing perspective, similar to other WAN routers. I've done this quite a bit, haven't had any issues, although if WAN routers are using BGP across a L3 VPN cloud, you got to think some about how you're going to route across VPN.
I've used DMVPN, GRE/IPSec and VTI tunnels.