Michael, that is correct, as far as your inside interface does not changes you can managed all the external chnages from PDM connection and CLI at the same time.
As for your second question on PDM updating rules in theory yes, I say theaory only for one reason just to have a full backup of all access-list rules just in case, I have done PIX outside re-IP %100 through PDM which automatically takes care of the rest, rules clear xlates updates automatically etc... When you do the static NATs if any from outside and DMZ do them one by one since PIX have to delete and recreate what is in the fules, the same applied for outside GLOBAL pools and PAT , do them one by one and take notes from old in case you need to revert back, global POOLS are the easiest to re-ip. If you are preparing this implementation it is also good to have a manual script just in case you need to do things in CLI but overall you should be good with PDM.
HTH
Jorge
Jorge Rodriguez