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Hints include: shape for end-to-end bandwidth if less than physical bandwidth, avoid fragmentation (enable PMTUD across tunnel and use tcp mss adjust), if shaper doesn't account for L2 overhead - adjust rate to allow for it, if doing VoIP you may need to reduce shaper's Tc, you may want/need to decrease TX ring limit, don't share Internet link with non-VPN traffic or use multiple tunnels that might oversubscribe bandwidth.
I've found with above, quality usually good across Internet even with mixed carrries because usually only the Internet ingress and egress points congest.
