Re: SHould I set speed/duplex at the trunk to Core Switch 4506?
Leaving it on AUTO/AUTO will be fine as it would autonegotiate to the max supported speed duplex settings on both the devices. you can try setting the speed only if you are facing problem of the links being negiotiated to less than the max speed.
I dont think it would affect the network speed as long as the link is autonegotiated to correct 1000/full.
We are pleased to announce availability of Beta software for 16.6.3. 16.6.3 will be the second rebuild on the 16.6 release train targeted towards Catalyst 9500/9400/9300/3850/3650 switching platforms. We are looking for early feedback from custome...