Hi Dominick,
Is the SMA supposed to have internet access?
This message is usually referring to the appliance trying to reach the Update Manifest server.
I'd try this in the SSH/CLI:
-telnet
-(select the interface configured to fetch updates)
-update-manifests.ironport.com
-443
If this fails, then it sounds like a connectivity issue.
Anyways, the SMA doesn't really have any updates (such as scanning engines/reputation scores) to fetch so at this point, it is probably just cosmetic. But access to that site from the SMA is needed for an upgrade.
You can also view the current Updater Logs on the SMA to see if the problem is still occuring.
-Vance